How are all the structures in your body affected by cold weather and why do our fingers, toes, and nose end up with frostbite first? When we start getting cold, the tissue and organs in our extremities do not get as much warm blood as our more important internal organs. Next, ice crystals start to form in our cells causing them to die. Finally, rewarming the tissue can cause damage resulting in problems with muscles, tendons, and bone. This video and lesson integrate essential vocabulary for the NC science curriculum. The explanation of this winter medical issue includes an engaging way to introduce students to human body organization.