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        9-12

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        Faces of America | I Dream of Genome

        This lesson plan, using video from the PBS series Faces of America, explores the various types of genetic information contained in the human genome.

        Lesson Summary

        Overview

        One of our strongest desires as humans is to know our roots – where we came from, and why we are the way we are. In recent years, we have been able to discover more information about ourselves than ever before, thanks to the sequencing of the human genome. Biologists, geneticists, historians and genealogists have all studied this fascinating and complex structure to find out what it can tell us about ourselves and our origins.

        This lesson, using segments from the PBS series Faces of America, explores the various types of genetic information contained in the human genome. The Introductory Activity examines the structure and composition of chromosomes and DNA, and can be used as a review or introduction to the topic. Following that, students will participate in a hands-on activity reviewing basic Mendelian genetics and the difference between genotype and phenotype. Students will also learn about different ways of tracing ancestry through DNA, and apply that to patterns of human migration and genetic population sets known as haplogroups. In the Culminating Activity, students will develop methods for determining the genetic heritage of their class, school, or community.

        Objectives

        Students will be able to:

        • Identify chemical and structural properties of DNA
        • Define “genotype” and “phenotype,” and explain the difference between the two
        • Describe how Y-chromosome DNA and mitochondrial DNA are used to trace ancestry and family lineage
        • Recognize and identify discrete population groups and paths of human migration
        • Develop a scientific investigation to determine the ethnic heritage of a large group of people

        Grade Level:

        9-12

        Suggested Time

        (3 - 4) 45-minute classperiods

        Media Resources

        Journey into DNA Flash Interactive

        Frenetic Genetics QuickTime Video

        All in the Family QuickTime Video

        Migration Sensations QuickTime Video

        A Piece of the Pie QuickTime Video

        Materials

        For each student:

        For each pair or group:

        • Computer, if not available for each student

        For the class:

        Web Sites

        Human Genome Project: Human Genome Project Information

        This website provides detailed information on the Human Genome Project (HGP), a project completed in 2003.

        National Geographic Genographic Project

        An ongoing project by National Geographic to traces the roots of human origin through DNA.

        Population Genetics

        This online interactive shows users how DNA mutations affect future generations.

        Before The Lesson

        Prior to teaching this lesson, you will need to:

        Preview all of the video segments and websites used in the lesson.

        Download the video segments used in the lesson to your classroom computer, or prepare to watch them using your classroom’s Internet connection.

        Bookmark the websites used in the lesson on each computer in your classroom. Using a social bookmarking tool such as del.icio.us or diigo (or an online bookmarking utility such as portaportal) will allow you to organize all the links in a central location.

        Print enough copies of each organizer for each student in your class, and print the answer keys for your reference.

        Note: In order to effectively conduct Learning Activity 3, class must have access to a computer lab or computers in the classroom. Students must be able to work at computers individually, in pairs, or in groups.

        The Lesson

        Part I: Introductory Activity

        1. Begin by asking your students what they already know about DNA. (Answers will vary, based on grade level and curriculum. The basic answers that will likely come up are: DNA is contained in the nucleus, it is in a double helix (twisted ladder) structure, there are dominant and recessive genes for traits, every human cell has 2 sets of 23 chromosomes.) Tell your students, if it hasn’t been addressed in their answers, that DNA contains all of the genetic information that your body needs to develop and function. Explain that genes and DNA are complex structures, and that the students will be exploring them more thoroughly using an online interactive.

        2. Ask students to open the Journey into DNA Flash Interactive. Depending on how many computers are in your classroom, students can complete this activity individually, in pairs, or in groups. Distribute the Journey into DNA Student Organizer to each student. Divide the class in half, asking one half to complete the Function side of the organizer, and the other half to complete the Structure side of the organizer. Provide students with a media focus, asking them to notice any information presented in the interactive that has to do with the function/structure of DNA. Give students 10 – 15 minutes to go through the interactive, recording their observations in the appropriate column on the organizer.

        3. Review the answers with the class. Ask studentsto fill in any missing information on their organizers.

        4. Ask students if they have ever heard of the genome, and if so, what they know about it. (Answers will vary, many students may mention the Human Genome Project.) Tell them that the genome comprises all of an organism’s genetic information, including DNA. The order, or sequence, of the bases in each strand of DNA is what is responsible for the information that determines and organism’s appearance, behavior, etc. There are three billion pairs of bases in the human genome. Tell the class that in 1990, a project was launched that would attempt to discover the sequence of all of these three billion bases, called the Human Genome Project.  The project, which completed its goals in 2003, determined the sequence of the three billion bases, and identified all genes found in humans. If students are interested in more information, they can visit the official website for the Human Genome Project: Human Genome Project Information.

        Part II: Learning Activity 1

        1. As we learned from the Human Genome Project, there are approximately 20,000 – 25,000 genes contained in human DNA. For most genes in the human genome, there are at least two alleles, or different forms of the gene. This is why not everybody looks alike – we have different combinations of alleles. An individual’s particular combination of alleles is called a genotype. Genotype can refer to either all of the genes a person has, or just the alleles in one particular gene. However, the genotype doesn’t necessarily indicate what a person will look like on the outside. The physical expression of a person’s genetic makeup is called a phenotype.

        2. Ask all students to stand up. Ask those students with freckles to move to the left side of the room. Ask those students without freckles to move to the right side of the room. Explain to the students that you have just classified them by phenotype – the physical manifestation of their freckle gene.

        3. Now ask students to think about their parents, and whether or not they have freckles. Ask students to move based on whether or not their parents have freckles. If both parents have freckles, move to the left side of the room. If only one parent has freckles, stand in the middle of the room. If neither parent has freckles, move to the right side of the room. Tell students that you have now classified based on their genotype – their genetic makeup.

        4. Look around the room. Did any of the students change places from the phenotype classification to the genotype classification? Do any of the students on the right side of the room have freckles? Do all of the students on the left side of the room have freckles? What about in the middle of the room?

        5. Explain to students that their freckles (or lack thereof) are due to the genes and alleles they received from their parents. Draw a sample Punnett square on the board, and explain to your students that F represents the dominant allele for freckles, and f represents the recessive allele for no freckles. Show an example of a square for a student who has freckles, and only has one parent with freckles.

        I Dream of Genome Image

        Explain to students that their genotype is Ff, indicating that they should have freckles. Their phenotype matches their genotype, since they have freckles. Distribute the What’s Your Genotype? Student Organizer to each student, and ask them to fill in the Punnett square to determine their own genotype.

        6. Explain to students that phenotype can be affected by other factors, and is not always aligned with genotype. For example, maybe neither of your parents have freckles, but when you were a child you spent a lot of time in the sun and developed some freckles. Your genotype is still ff, indicating that you are not genetically determined to have freckles, but your phenotype is different.

        7. Explain to students that in the PBS series Faces of America, Harvard University professor Dr. Henry Louis Gates, Jr. has his genome sequenced, and gets to take a very close look at his genotype. Tell students that you are going to show them a video from the series, reviewing some of the alleles and traits present in Dr. Gates. Provide students with a media focus by asking them to observe which variants mentioned in the video relate to Gates’s genotype, and which describe his phenotype. Play Frenetic Genetics. When the segment has finished, ask students what Dr. Gates learned about his genotype (variants for lactose intolerance, epiphyseal development, no baldness, 1 sickle cellallele – both are required for the disease, no variant for early onset Alzheimers, resistance to malaria, high tolerance for caffeine). How were these genetic variants represented in Gates’s phenotype? (Slipped epiphysis resulting in fractured hip, hair texture and how much hair he’ll keep, inability to eat milk or ice cream.)

        8. Your students have just heard many examples of different physical and behavioral traits, such as freckles, lactose intolerance, bone weakness, and propensity for diseases.  Ask students to speculate why there are different alleles for these genes, or why there are differences or variations in these traits.  (Answers will vary, encourage discussion among students.)

        Part III: Learning Activity 2

        1. Now that we’ve learned what our genes tell us about ourselves, we can learn what our genes tell us about our ancestors. Explain to students that genetic research can be used in addition to paper records to determine one’s ancestry. Tell students that you are going to show them a segment from the public television series Faces of America, in which host Henry Louis Gates, Jr. aims to uncover genealogical information about himself and his guests. Provide students with a media focus by asking them to write down the attempts to trace ancestry seen in the segment, and note if they are through maternal or paternal lines. Play All in the Family. When segment is finished, review answers with the class. (Henry Louis Gates, Jr. attempting to find his second great-grandfatherthrough paternal lines; Elizabeth Alexander tracing her ancestry through maternal lines to her 24th great-grandparents.) Ask students how they think geneticists are able to determine a person’s ancestry. (Answers may vary; engage the class in a discussion. Students should come to understand that if the same genes are present in people from different generations then it is likely that they are related – similar to the alleles for freckles being passed from parent to child.)

        2. Project the NationalGeographic Genographic Project Genetic Signposts interactiveon a screen or interactive whiteboard for the whole class. Students may follow along on personal computers if available. Click on the button that says “Show recombined DNA.” Explain that this is regular nuclear DNA – genes and alleles - that has been passed down from generation to generation. As indicated by the multicolored chromosomes of the son and daughter, their recombined DNA is a random assortment of the genes of their ancestors. Read or ask a student to read the text at the top of the page.

        3. Explain that there are two types of DNA that are not shuffled randomly from generation to generation, and give definitions.

        Y-chromosome DNA: nuclear DNA that is particular to the Y-chromosome. Since the Y-chromosome is only found in males and doesn’t combine with any other chromosomes, it is passed down virtually unchanged from father to son.

        Mitochondrial DNA: non-nuclear DNA found in cell organelles called mitochondria. mtDNA is found in both men and women but does not recombine, as any mtDNA contained in sperm cells is lost in the fertilization process.  mtDNA is thus passed down virtually unchanged from mother to daughter.

        4. Click on the button that says “Show non-recombined DNA.” Your students should clearly see how yDNA and mtDNA is passed down from generation to generation.

        As students can see, by using yDNA and mitochondrial DNA it is possible to find connections between people across generations. Explain to students that this information also allows people in the same generation to find genetic connections with each other as well. Project the Tracing Ancestrywith mtDNA interactiveon a screen or interactive white board, and ask students to follow on personal computers (or distribute printout to each student if computers are not available). Give students approximately 5 minutes to complete the activity. Remind students that while all of the people in the “great, great, greatgrandparents” generation are the ancestors of the current generation, only one shares mitochondrial DNA with everyone in the current generation.

        Part IV: Learning Activity 3

        1. yDNAand mtDNA can also be used to trace human ancestry on a grander scale.  This is due to the fact that yDNA and mtDNA do experience changes occasionally. Go to the Population Genetics interactive. Read or ask a student to read the text at the top of page 1. Click on the button that says “Click to Compare,” and ask students to find the mutation. Explain that these random mutations, when passed down through generations, become inheritable genetic markers. Go to page two of the interactive. Read or have a student read the text. Ask students to click through the interactive, asking them to pay attention to the number of genetic markers in each generation. When students have completed the interactive, ask the class for a definition of haplotype. (Combination of genetic markers.) Note that even when other markers appear, the original marker is still present. Explain that population groups sharing the same haplotype are called haplogroups. The study of haplogroups is valuable for tracing paths of human migration and development, in order to find common ancestors. Direct students to page five of the Population Genetics interactive. Read or ask a student to read the text at the top of the page. Ask students to click on the buttons to see the different divisions of haplogroups.

        2. Tell students that you are going to show them a segment from the series Faces of America, in which Dr. Henry Louis Gates, Jr. reveals the maternal (or mtDNA) haplogroups of three of his guests. Provide students with a media focus by asking them to observe where the human population is thought to have originated, and how it spread over time. Play Migration Sensations. When the segment is finished, ask students where, according to the segment, humans originated. (East Africa.) Following that, when and where did human populations spread? (East and north of Africa, in Southeastern Asia during the Ice Age, Central and East Asia and the Americas about 16,000 years ago, to Europe after the end of the last Ice Age.)

        3. Tell students that you would now like them to explore human migratory paths, haplogroups, and common ancestors in more detail. Direct students to the Atlas of the Human Journey interactive, and distribute the Atlas of the Human Journey Student Organizer to each student in the class. Depending on how many computers are in the classroom, students can view the interactive in pairs or groups, but each student should complete the activity individually. Ask students to click on the right-most box in the timeline, 10 – 5,000 B.C. They can see that there are many haplogroups represented, both mtDNA andy-chromosome. Ask students to look at the map, and pick the haplogroup line that best corresponds to the area where they and their ancestors are from. (If any student cannot find an appropriate haplogroup, or they are not familiar with where their ancestors are from, they can choose one at random.) Ask the male students to pick a blue line, representing a y-chromosome haplogroup, and the female students to pick an orange line, representing an mtDNA haplogroup. When the line is clicked, a text box will appear with information about that haplogroup. Ask students to read the text, and fill in the appropriate information in the first box on their organizer.

        4. Students should continue to trace their haplogroup lines back as far as they can, until they arrive at the spots on the map that read “Adam” (for y-chromosome haplogroups) or “Mitochondrial Eve” (for mtDNA haplogroups). It is possible that some students will need more than one organizer sheet to complete the activity, as there will be many different haplogroups in their line.  Ask students to circle the information about the last haplogroup in their line. Allow students 20 – 30 minutes to complete the activity, depending on how many students are working at each computer.

        5. When the activity has been completed, ask the class the following questions to engage the class in discussion:

        • What was the last haplogroup in your line? (Male students should answer Haplogroup A(M91); female students should answer Haplogroup L0 or L1.) How many years ago did that haplogroup originate? (Haplogroup A (M91) originated approx. 55,000 years ago, L0 and L1 originated approx. 150 – 170,000 years ago.) Ask students why they think the distribution of yDNA and mtDNA haplogroups is different. (Accept all answers and encourage discussion; explain to students that since mtDNA and y-chromosome DNA have different mutation rates the respective haplogroups divided and proliferated differently.)
        • Was there anything that surprised you about your haplogroup’s path?  Does your haplogroup appear in places that you didn’t expect?

        Part V: Culminating Activity

        1. Remind students that based on one’s haplotype or haplogroups, it’s conceivable that one could trace their ancestors and their lineage much further back than traditional genealogy would allow. Explain that this concept is the basis of the field of genetic genealogy, which aims to determine the genetic relationships between individuals and families over time. Tell students that there are many methods and tests that claim to be able to tell you your genetic ethnic heritage. One of these is called an admixture test, which reveals the geographical regions represented by your DNA markers. Tell students that they will be watching a video from Faces of America in which the series’ guests learn the results of their own admixture tests. Provide students with a media focus by asking them to observe which geographic areas are represented in the admixture results. Play A Piece of the Pie. When the video has finished playing, review the focus question with students and ask for their answers. (Europe,Asia,Africa.) Point out that in the segment, Dr. Gates states that according to the admixture results, “Asian and Native American are the same.” Ask students what they think the reason for that may be. (Native America populations migrated to America from Asia, so they would likely have the same genetic markers.) Explain that even the “indigenous Mexicans” that Eva Longoria mentions have ancestors from Asia, going back tens of thousands of years.

        2. As we can see by the range of guests in Faces of America, the paths of human migration continues to this day. None of the people in the segment identify as Native American, yet they all wound up living in America. Henry Louis Gates, Jr. set out to explore this stage of human migration by exploring how all of these individuals came to reside in America. Ask your students, what can you do in our community to explore the paths of human migration. How would you determine how everyone in the class/school/community came to be living not just in this country, but in this town or city?

        3. Tell students that you would like them to develop an experiment or research model that would effectively trace the genetic heritage of the class/school/community. Distribute the Genetic Heritage Investigation Student Organizer, and tell students they are welcome to use this to construct their experiment. Divide students into pairs or groups to work on the project. Students should use the rest of the class period to work, and can complete the assignment over the course of the next day (or as many days as you choose to allot) as class work or homework.

        4. As an assessment, have pairs/groups present their ideas to the class.

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