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        Grades

        9-13+

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        Cell Replication and Cancerous Cells

        Students explore mitosis and learn about uncontrolled cell division, or cancer.

        Lesson Summary

        Overview

        In this activity, students learn why cell growth is limited and requires cell division. They explore the different phases of mitosis in a Web activity. They learn about uncontrolled cell division--cancer, the oncogenes that cause it, and possible treatments. Finally, as an optional exercise, they consider different points of view concerning the cloning of humans.

        Objectives

        • Learn why cell growth requires cell division
        • Explore how cells divide by the process of mitosis
        • Understand the role of oncogenes in the development of cancer
        • Analyze different points of view regarding human cloning

        Suggested Time

        • Two to three class periods

        Multimedia Resources

        Optional Multimedia Resources

        Materials

        • Two round balloons (for cell growth demonstration)

        Before the Lesson

        • Review the concepts of cell structure and function, using the lesson App Exception: tdc02.sci.life.cell.lp_strufx. Make sure students understand the gatekeeper role of the cell membrane.

        After the Lesson

        • Do an experiment with students to demonstrate how the surface-area-to-volume ratio affects the rate of diffusion of substances into and out of cells. (See BSCS Biological Science: An Ecological Approach for a possible lab.)

        The Lesson

        Part I

        1. Blow up a balloon and tie it off. Tell students that the balloon represents a cell. Then blow up a second balloon larger than the first and tie it off. Ask students:

        • As a cell grows, what happens to its surface-area-to-volume ratio (the size of the cell membrane compared to the amount of space taken up by the contents of the cell)? (Note: Assume a cell is a perfect sphere. The formula for calculating the surface area of a sphere is A = 4 π r2. The formula for calculating the volume of a sphere is V = 4/3 π r 3.)

        Now explain how this changing ratio is related to cell division. Ask:

        • How would a smaller ratio (i.e., a smaller surface area per volume) affect the cell's ability to function?
        • How large do you think a cell could grow and still be able to function before it would need to divide?
        • How can organisms like humans grow larger despite the constraints to cell size?

        2. Show the Mitosis video with the sound off.

        • Ask students to describe in their own words what is happening and how this process helps an organism stay alive and healthy.
        • Say to students: In the time it took to watch this video, you lost 40,000 skin cells, yet you are not skinless. How does what you saw explain why this is so?

        3. Show the Mitosis video again, this time with the sound on. Have students explore the How Cells Divide: Mitosis vs. Meiosis interactive activity, and then ask them to draw and briefly describe each phase of mitosis.

        4. Ask students:

        • What would happen if mitosis within an organism were uncontrolled?
        • What do you think regulates cell division in organisms?

        5. Show the video How Cancer Cells Grow and Divide. Discuss the following:

        • What other kinds of signals do you think cells would respond to that would make them grow and divide appropriately?
        • Why do you think the oncogene acts as though it is stuck in the "on" position?
        • How might scientists use knowledge about receptors and how metastasis occurs to find ways to stop cancer?

        6. Have students explore the Web activity How Cancer Grows to learn more about cancer growth and treatments for cancer. Discuss the following:

        • What are some ways cancer cells develop abnormally?
        • What are some ways that cancer cells differ from normal cells of the same kind of tissue?
        • How does the body respond to cancer cells?

        7. Ask:

        • What is the process that single-celled organisms like the paramecium or amoeba use to reproduce asexually? How genetically similar are their offspring?
        • "There are millions of clones walking on earth." What do you think this statement means?

        8. Then have students explore the different points of view in theOn Human Cloning article. Discuss the following:

        • What would it mean to "clone" a human?
        • How would a cloned human be different from other humans?
        • Besides helping infertile couples, in what other ways might cloning help people?
        • From a scientific point of view, what are the strengths and weaknesses of each researcher's argument?
        • Do you think the word cloning means something different to a scientist than to a layperson?

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